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KMID : 0032220070190020060
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Annals of Dermatology
2007 Volume.19 No. 2 p.60 ~ p.67
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Effect of Trans-4-Aminomethylcyclohexanecarboxylic Acid on the Proliferation and Melanization in Cultured Normal Human Melanocytes
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Seo Seong-Jun
Cho Wan-Ik
Kim Myeung-Nam
Cho Sung-Hyun
Jeong Mi-Sook
Ro Sung-Wook
Hong Chang-Kwun
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Abstract
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Background: Trans-4-aminomethylcyclohexanecarboxylic acid (tranexamic acid) has recently been reported to inhibit prostaglandin synthesis and hinder the pigmentation caused after UV radiation.
Objective: we evaluated the influence of tranexamic acid on the viability, morphogenesis and melanization of cultured normal human melanocytes.
Method: The cultured melanocytes from neonatal foreskin were exposed to UVB 20mJ/cm2, then treated with tranexamic acid [0.05microgram/ml, 0.05microgram/ml, and 0.5microgram/ml]. After 24 hours, the viability of melanocytes and the melanin concentration was measured. The number and length of the melanocytes’ dendrites, and the expression level of tyrosinase, TRP-1 and TRP-2 were also evaluated.
Results: The viability of the melanocytes was decreased by tranexamic acid in a dose dependent manner (p<0.05). The increased melanin synthesis by UVB irradiation was decreased by tranexamic acid in a dose dependent manner (p<0.05). Also, the increased expressions of TRP-1, TRP-2 and tyrosinase after exposure to UV were statistically decreased by tranexamic acid in a dose dependent manner (p<0.05).
Conclusion: tranexamic acid may prevents UVB induced pigmentation.
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KEYWORD
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Melanocytes, Tranexamic acid, UVB
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